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Daily i.p. injection of 5''-N-Ethylcarboxamidoadenosine (NECA) at 0.3 mg/kg/day for two weeks reduces malondialdehyde (MDA) levels in diabetic rats, but does not affect control rats. Daily treatment with NECA (0.3 mg/kg/day, i.p. for two weeks) reduces diabetes-induced gene expression of tumor necrosis factor (TNF)-α and interleukin (IL)-18 in diabetic rats, but does not affect control rats.
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Clinically, some of these patients respond to empirical use of long-acting nitrates or calcium channel blockers, either daily or during days of the month when they are predictably symptomatic. Although the use of these agents may be limited by adverse effects of hypotension or headaches, empirical therapy may be considered if the patient’s symptoms are relieved with short-acting nitrates.
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Injection of a local anesthetic or corticosteroid, coined with the acquisition of a semisupinated oblique radiograph, enables the diagnosis of pisotriquetral joint dysfunction. Semisupinated oblique views clearly demonstrate loose bodies in the superior and inferior recesses of the pisotriquetral joint in cases of associated secondary osteochondromatosis ( , Fig 20 , ).
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Optogenetic Dissection of Entorhinal-Hippocampal …
Two to 3 weeks after viral injection, robust labeling of EYFP fluorescence could be observed in all subfields of the dorsal hippocampus at and around the injection sites (). In addition, EYFP-positive neurons could be identified in layers II and III of MEC, which indies that the rAAV2/1 vector had infected cell bodies of MEC neurons with projections to the hippocampal injection site.